Mathematical Model of the Relationship between Preeclampsia Markers SFLT-1 and PLGF
https://doi.org/10.56304/S2304487X21020024
Abstract
One of the results of mass screening of pregnant women in the Moscow region has been reported. The screening purpose is to detect prognostic signs of preeclampsia, which is a severe pregnancy complication. In the screening process for each patient, the placental concentrations of angiogenic PLGF protein and anti-angiogenic SFLT-1 protein in blood serum have been measured. According to the medical literature, these proteins can serve as signs (markers) of possible preeclampsia development. Statistical processing of screening data has been carried out using tools of our logical symptom method. In a sample containing 564 patients without preeclampsia, the dependence of the concentration of each of the markers on the gestational period has been obtained. A mathematical model of the relationship between the concentrations of markers during pregnancy is constructed. The model demonstrates that the concentration of the SFLT-1 marker in the first half of pregnancy in patients without preeclampsia monotonously “follows” an increase in the concentration of the PLGF marker. The former concentration continues to monotonically increase in the second half of pregnancy, when the latter concentration decreases. In patients with preeclampsia, the behavior of the concentration of the SFLT-1 marker inhibitor is catastrophically changed: in the second half of the pregnancy, its concentration increases sharply and remains high until the end of pregnancy. Thus, the effectiveness of these markers is confirmed as signs of preeclampsia in the late periods of pregnancy.
About the Authors
V. M. Guryeva
Moscow Regional Research Institute of Obstetrics and Gynecology
Russian Federation
Russian Federation
101000
Moscow
Yu. B. Kotov
Keldysh Institute of Applied Mathematics, Russian Academy of Sciences
Russian Federation
Russian Federation
125047
Moscow
M. O. Matveev
Moscow Regional Research Institute of Obstetrics and Gynecology
Russian Federation
Russian Federation
101000
Moscow
T. A. Semenova
National Research Nuclear University MEPhI (Moscow Engineering Physics Institute)
Russian Federation
Russian Federation
115409
Moscow
A. A. Travkina
Moscow Regional Research Institute of Obstetrics and Gynecology
Russian Federation
Russian Federation
101000
Moscow
T. S. Budykina
Moscow Regional Research Institute of Obstetrics and Gynecology
Russian Federation
Russian Federation
101000
Moscow
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Review
For citations:
Guryeva V.M., Kotov Yu.B., Matveev M.O., Semenova T.A., Travkina A.A., Budykina T.S. Mathematical Model of the Relationship between Preeclampsia Markers SFLT-1 and PLGF. Vestnik natsional'nogo issledovatel'skogo yadernogo universiteta "MIFI". 2021;10(2):129-134. (In Russ.) https://doi.org/10.56304/S2304487X21020024
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