Mathematical Simulation of Inhalation Effects of Hazardous Chemicals in Industrial Premises
https://doi.org/10.1134/S2304487X21010065
Abstract
It is known that the excess of maximum one-time concentrations of harmful substances in the air of the working area is one of the main reasons for an increase in the level of occupational diseases in various industries (primarily chemical). In order to determine the cause of occupational diseases, assess their consequences, as well as develop a set of measures aimed at their prevention, it is necessary to establish a connection between such effects with the manifestation of occupational diseases, as well as to assess the incidence of diseases in occupational groups. Thus, the problem of assessing the impact of vapors, fine aerosols, and dust particles of hazardous chemicals used in technological processes that can be in the air of working rooms on personnel is extremely important, and studies aimed at quantifying the inhalation effects of hazardous chemical substances on personnel, are relevant. In this work, repeated short-term inhalation effects of hazardous chemicals on the working personnel of chemical enterprises are mathematically simulated, the developed software package including a database of hazardous chemicals and mathematical models that allow simulating toxicokinetics during inhalation effects on personnel in working rooms, as well as assessing risk to personnel, has been described.
About the Authors
D. E. Ivanov
State Research Institute of Organic Chemistry and Technology
Russian Federation
Russian Federation
111024
Moscow
T. N. Shvetsova-Shilovskaya
State Research Institute of Organic Chemistry and Technology
Russian Federation
Russian Federation
111024
Moscow
O. V. Polekhina
State Research Institute of Organic Chemistry and Technology
Russian Federation
Russian Federation
111024
Moscow
F. I. Skvortsov
State Research Institute of Organic Chemistry and Technology
Russian Federation
Russian Federation
111024
Moscow
References
1. Polekhina O. V., Vikent’eva M. A., Shvecova-Shilovskaya T. N., Gromova T. V. Matematicheskoe modelirovanie toksikokinetiki pri ingalyacionnyh vozdejstviyah promyshlennyh toksikantov [Mathematical modeling of toxicokinetics under inhalation exposure to industrial toxicants]. Himiya i tekhnologiya organicheskih veshchestv, 2018, no. 3 (7). pp. 55–66.
2. Valeeva E. T., Bakirov A. B., Karimova L. K. Professional’nyj risk dlya zdorov’ya rabotnikov himicheskoj promyshlennosti [Occupational health risks for chemical workers]. Vestnik RGMU, 2013. no. 5–6, pp. 124–128.
3. Valeeva E. T. Nauchnoe obosnovanie sistemy ohrany zdorov’ya rabotnikov himicheskoj promyshlennosti na osnove ocenki professional’nogo riska. Dok. med. nauk. avtoref. diss. [Scientific substantiation of the health protection system for workers in the chemical industry based on an assessment of occupational risk]. Moskva. 2013. 48 p.
4. Tolokonceva N. A., Filova V. A. Osnovy obshchej promyshlennoj toksikologii (rukovodstvo) [Fundamentals of General Industrial Toxicology (manual)]. Leningrad, Medicina. Leningradskoe otdelenie, 1976. 304 p.
5. Li D., Morishita M., Wagner J. G., Fatouraie M. In vivo biodistribution and physiologically based pharmacokinetic modeling of inhaled fresh and aged cerium oxide nanoparticles in rats, Particle and Fibre Toxicology, 2016. doi: 10.1186/s12989-016-0156-2
6. Jonsson F., Bois F., Johanson G. Physiologically based pharmacokinetic modeling of inhalation exposure of humans to dichloromethane during moderate to heavy exercise, Toxicol. Sci. 2001. V. 59. P. 209–218.
7. Willems B. A. T., Melnick R. L., Kohn M. C., Portier C. J. A physiologically based pharmacokinetic model for inhalation and intravenous administration of naphthalene in rats and mice, Toxicol. appl. pharmacol. 2001. V. 176. P. 81.
8. Dershwitz M., Walsh J. L., Morishige R. J. Pharmacokinetics and pharmacodynamics of inhaled versus intravenous morphine in healthy volunteers, Anesthesiology. 2000. V. 93. P. 619–628.
9. Langenberg J. P., Spruit H. E. T., Van der Wiel H. J. Inhalation toxicokinetics of soman stereoisomers in the atropinized guinea pig with nose-only exposure to soman vapor, Toxicology and Applied Pharmacology. 1998. V. 151 (1). P. 79–87.
10. Piotrovski E. Ispol’zovanie kinetiki metabolizma i vyvedeniya toksicheskih veshchestv v reshenii problem promyshlennoj toksikologii (per. s angl.) [Using the kinetics of metabolism and elimination of toxic substances in solving problems of industrial toxicology (translated from English)]. Moscow, Medicina. 1976. 194 p.
11. Solov’ev V. N., Firsov A. A., Filov V. A. Farmakokinetika (Rukovodstvo) [Pharmacokinetics (Manual)]. Moscow, Medicina. 1980. 423 p.
12. Onishchenko G. G., Novikov S. M., Rahmanin Yu. A. Osnovy ocenki riska dlya zdorov’ya naseleniya pri vozdejstvii himicheskih veshchestv, zagryaznyayushchih okruzhayushchuyu [Fundamentals of risk assessment for public health when exposed to chemicals that pollute the environment]. Moscow, NII ECH i GOS. 2002. 408 p.
13. Rukovodstvo po ocenke professional’nogo riska dlya zdorov’ya rabotnikov. Organizacionno-metodicheskie osnovy, principy i kriterii ocenki. Rukovodstvo R 2.2.1766-03 [Guidelines for assessing occupational health risks for workers. Organizational and methodological foundations, principles and evaluation criteria. Guideline R 2.2.1766-03.]. Moscow, Federal’nyj centr gossanepidnadzora Minzdrava Rossii. 2004. 24 p.
14. Rukovodstvo po ocenke riska dlya zdorov’ya naseleniya pri vozdejstvii himicheskih veshchestv, zagryaznyayushchih okruzhayushchuyu sredu. Rukovodstvo R 2.1.10.1920-04 [Guidelines for assessing the risk to public health when exposed to chemicals that pollute the environment. Guideline R 2.1.10.1920-04]. Moscow, Federal’nyj centr Gossanepidnadzora Minzdrava Rossii. 2004. 143 p.
Review
For citations:
Ivanov D.E., Shvetsova-Shilovskaya T.N., Polekhina O.V., Skvortsov F.I. Mathematical Simulation of Inhalation Effects of Hazardous Chemicals in Industrial Premises. Vestnik natsional'nogo issledovatel'skogo yadernogo universiteta "MIFI". 2021;10(1):31-40. (In Russ.) https://doi.org/10.1134/S2304487X21010065
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